Mononucleosis, commonly known as mono, is a viral infection that most often affects teens and young adults. Caused primarily by the Epstein-Barr virus (EBV), mono is notorious for leaving people feeling exhausted for weeks or even months. But what happens if you start feeling mono symptoms again after recovering? Can mono come back? It’s a question many people have, especially when they start feeling symptoms again after initial infection. In this blog, we’ll explore whether mono symptoms can return, why they might reappear, and when it’s time to seek professional care.
For same-day mono testing and treatment, visit the walk-in clinic at AFC Urgent Care Denver Leetsdale. Our medical team is available 7 days a week to provide quality, convenient, and affordable care in Denver, CO. Walk in or plan your visit in advance below.
What Is Mono?
Mononucleosis is a viral illness caused most often by the Epstein-Barr virus (EBV), which is part of the herpesvirus family. It can spread through saliva and other bodily fluids, hence the nickname “kissing disease.” Symptoms usually develop 4 to 6 weeks after exposure and can last anywhere from 2 to 6 weeks. However, some symptoms like fatigue can persist for months in some cases.
Common mono symptoms include:
- Extreme fatigue
- Swollen lymph nodes
- Sore throat
- Fever
- Headache
- Enlarged spleen or liver
Can Mono Come Back?
Technically, mono doesn’t “come back” in the same way that some other infections might. Once you’ve had mono, the Epstein-Barr virus stays in your body for life– but it typically becomes dormant and doesn’t cause further problems. That said, there are several scenarios where mono-like symptoms can reappear, and understanding them can help you determine your next steps.
Reasons You May Feel Like Your Mono Symptoms Are Returning
1. Post-Viral Fatigue
Fatigue is one of the most lingering symptoms of mono. Even after the initial infection clears, your body may still be recovering. Many people experience waves of tiredness, low energy, or brain fog for weeks or months after other symptoms disappear. This post-viral fatigue doesn’t mean you’re reinfected. It’s just your body’s long recovery process. Pushing yourself too hard during this time can cause setbacks.
2. EBV Reactivation
Although rare, the Epstein-Barr virus can reactivate in some people. This is more likely in individuals with weakened immune systems, such as those undergoing chemotherapy or living with autoimmune conditions. In these cases, the virus may start reproducing again, potentially causing mild symptoms similar to mono. EBV reactivation usually doesn’t cause the full-blown illness again, but can cause low-grade fever, fatigue, sore throat, and swollen lymph nodes.
3. Another Illness With Similar Symptoms
Several illnesses can mimic mono symptoms. This includes strep throat, influenza, COVID-19, and anemia or thyroid disorders. If you’re feeling run down again, it could be something entirely new. This is especially true if your symptoms are accompanied by high fever, body aches, or respiratory symptoms not typical of mono.
When To Visit Urgent Care
While mono is generally a self-limiting illness, there are times when a visit to urgent care is a smart move, especially if you’re experiencing:
- Return or severe sore throat or fever
- Persistent fatigue that interferes with daily life
- New or worsening symptoms
- Pain in the upper left abdomen
- Concerns about exposure to another illness
An urgent care provider can perform a physical exam, check for complications, run rapid tests, and help rule out other complications.
Get Walk-In Mono Testing and Treatment at AFC Urgent Care Denver Leetsdale
While mono itself usually doesn’t come back in full force, it’s not uncommon to experience a return of certain symptoms like fatigue or mild sore throat. This could be due to lingering effects of the original infection, overexertion, or another illness altogether. In rare cases, the EBV virus can reactivate, but this usually results in milder symptoms. If you’re unsure why you’re feeling sick again after having mono– or if your symptoms are getting worse– come visit the walk-in clinic at AFC Urgent Care Denver Leetsdale. We can help provide clarity and the right course of treatment to get you back on your feet. For more information about the services we provide, please contact us directly at (303) 935-1000.
